Effect of an Herbal Extract Containing Curcumin and Piperine on Midazolam, Flurbiprofen, and Acetaminophen Pharmacokinetics in Healthy Volunteers

نویسندگان

  • Laurie P. Volak
  • Michael J. Hanley
  • Gina Masse
  • Suwagmani Hazarika
  • Jerold S. Harmatz
  • Vladimir Badmaev
  • Muhammed Majeed
  • David J. Greenblatt
  • Michael H. Court
چکیده

British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society 1 BJCP-MP-00089-12-R1 Effect of an Herbal Extract Containing Curcumin and Piperine on Midazolam, Flurbiprofen, and Acetaminophen Pharmacokinetics in Healthy Volunteers Laurie P. Volak, Michael J. Hanley, Gina Masse, Suwagmani Hazarika, Jerold S. Harmatz, Vladimir Badmaev, Muhammed Majeed, David J. Greenblatt, and Michael H. Court

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Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers

The medicinal properties of Curcumin obtained from Curcuma longa L. cannot be utilised because of poor bioavailability due to its rapid metabolism in the lover and intestinal wall. In this study, the effect of combining piperine, a known inhibitor of hepatic and intestinal glucuronidation, was evaluated on the bioavailability of Curcumin in rats and healthy human volunteers. When Curcumin was g...

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The medicinal properties of curcumin obtained from Curcuma longa L. cannot be utilised because of poor bioavailability due to its rapid metabolism in the liver and intestinal wall. In this study, the effect of combining piperine, a known inhibitor of hepatic and intestinal glucuronidation, was evaluated on the bioavailability of curcumin in rats and healthy human volunteers. When curcumin was g...

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تاریخ انتشار 2012